Science in Lendosa is given quite a high priority. It is under the broad control of the government's Science Section, with input from the various other Sections, and is carried out both by independent researchers and by the various governmental facilities. These facilities come in the form of various Institutes, government-established organisations dedicated to a particular focus of research. Only government organisations may use the term "institute" - private groups are called "research associations". Most Institutes are simply named after their field of study (The Institute of Marine Biology, for example), but some have unique names based on either historical figures or themes (such as the Alvare Institute or the Lomano Institute).

Independent research is of course permitted, and actively encouraged by the government, but is under strict control. All important research in certain fields must first be cleared by the Science Section, and possibly the Ethics Section, depending on the field. Furthermore, any important technology or knowledge developed within Lendosa must be granted a permit to be taken outside the country or sold.

The Lendosan Confederation is particularly respected in the field of particle and sub-atomic research, and many important discoveries were made by scientists from Lendia or Piolsa. The particle accelerator located at Riva, Lendia, is one of Vexillium's largest, and has been an invaluable assistance to research efforts into the nature of sub-atomic particles. Imbrio Lomano, the physicist who determined the structure of the atom and the charges of its components, was also Lendosan. Other areas in which Lendosa has strengths are oceanographic research, climatic and atmospheric sciences, computing, and communication technologies.

Lendosa is also a participant in the Free Confederate Community Space Agency, a space venture operated by several nations of the region, including Caboteniasa, Neoliliana, and Burovia. This continues the progress of the old FCLR space agency, regarded as one of the world's leading space organisations. The FCCSA is particularly strong in the field of ground-based observations and radio-telescope detection, but also conducts numerous satellite launches.